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Teratogenität des Wirkstoffes Acitretin: Ausweitung des Kontrazeptionszeitraumes nach Therapieende auf 3 Jahre

15. September 2016 – Der Wirkstoff Acitretin ist ein Retinoid, welcher zur Behandlung von schweren und schwersten Verhornungsstörungen der Haut (z.B. Psoriasis, Ichthyosis, Lichen ruber planus) in verschiedenen Ländern wie z.B. in Deutschland als Acicutan, in Österreich, Deutschland, und der Schweiz als Neotigason,

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  • Twenty four genetic variants linked to heightened womb cancer risk February 17, 2020
    Twenty four common variations in genes coding for cell growth and death, the processing of oestrogen, and gene control factors may be linked to a heightened risk of developing womb (endometrial) cancer, indicates the most comprehensive review of the published evidence so far in the Journal of Medical Genetics.
  • Researchers discover the link between ribs and lung function in patients with brittle bone disease February 17, 2020
    A multidisciplinary team headed by Valencia University (UV) professor Juan Alberto Sanchis Gimeno reports on the link between the shape of the ribs and lung function in patients with osteogenesis imperfecta, a rare disease that affects one of every 18,000 newborns. Their study has been published in the Journal of Advanced Research.
  • Key modifier found in genetic deletion related to neurodevelopmental disorders February 14, 2020
    Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes. In a new study, researchers evaluated the effects of over 300 pairwise knockdowns—reducing the expression of two genes simultaneously—of the fruit fly versions of genes located in a region of human chromosome 3 that, when deleted, has […]
  • Stress in small children separated from their parents may alter genes February 14, 2020
    Experts in the emotional needs of small children say increased levels of the stress hormone cortisol in babies and small children who are separated from their parents, especially their mothers, could have a long-term genetic impact on future generations. In a commentary published by the Journal of the Royal Society of Medicine, the authors say […]
  • Autophagy genes act as tumor suppressors in ovarian cancer February 13, 2020
    Shedding light on a decades-old controversy, scientists at the Medical University of South Carolina (MUSC) and University of California at San Diego (UCSD) published findings in PLOS Genetics this month showing that autophagy or "self-eating" genes work against tumors in certain types of ovarian cancer.
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