Last Updated on May 24, 2017 by Joseph Gut – thasso May 24, 2917 – The American Food & Drug Administration (FDA) just approved a major extension of the clinical indications for Pembrolizumab (Keytruda). For the first time,  a cancer treatment …

First cancer treatment for any solid tumor with MSI-H or dMMR approved Read more »

Last Updated on May 19, 2017 by Joseph Gut – thasso May 18, 2017 – Ivacaftor (Kalydeco) is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator indicated for the treatment of cystic fibrosis (CF) in patients age 2 years and older …

Theragenomics: Ivacaftor (Kalydeco) in the CFTR mutation-based treatment of cystic fibrosis (CF) Read more »

Last Updated on May 18, 2017 by Joseph Gut – thasso 18 May 2017 – According to a paper just published in PLOS One, research team from the University of Zurich found that individuals who agree to openly share their direct-to-consumer …

Motivation and dangers of sharing personal genetic data in the open space Read more »

Last Updated on May 17, 2017 by Joseph Gut – thasso May 17, 2017 – Following up on an earlier Drug Safety Communication from May 2016 and based on new data from two large clinical trials, the American Food & …

Risk of leg and foot amputations under Canagliflozin (Invokana, Invokamet) Read more »

Last Updated on May 15, 2017 by Joseph Gut – thasso May 14, 2017 – Hypertension is a leading cause of global disease, mortality, and disability. Individuals of African descent suffer a disproportionate burden of hypertension and its complications. To date, …

Populations of African descent: New trait loci for hypertension Read more »

Last Updated on May 7, 2017 by Joseph Gut – thasso Mai 07, 2017 – Genetics- and/or genomics-based approaches are penetrating every single aspect of human life. In contrast to the term theragenomics (therapy decisions with the help of  genetic/genomic …

Lifeomics: Epigenetic DNA methylation-based life insurance? Read more »

Last Updated on May 5, 2017 by Joseph Gut – thasso May 05, 2017 – This report nicely illustrates how, by both clever study design and selection of according phenotypic patients, genetic predispositions for even very rare serious adverse drug reactions …

Bisphosphonates: GGPS1 Mutation and Atypical Femoral Fractures Read more »

Last Updated on May 13, 2017 by Joseph Gut – thasso May 03, 2017 – Is there a genetic predisposition for usage of social media? The answer may be a qualified YES. It’s easy to think in terms of linking …

Is there a genetic predisposition for usage of social media? Read more »