25 June 2022 – Xalkori (Crizotinib)-related ocular toxicity and severe visual loss are difficult to detect in children. This comes out of a Dear Healthcare Professional Communication (DHPC) letter from the European Medicine Agency (EMA) following it’s June 2022 Pharmacovigilance Risk Assessment …

Xalkori: Ocular Toxicity and Severe Visual Loss in Children Read more »

June 23, 2022 – Expansion of pharmacogenetics education agreed as part of lawsuit settlement. This has just been the headline objective of one of the latest blogs from the PharmGKB blogspot, an NIH-funded resource (database) that provides information about how …

Real world theragenomics and personalised medicine Read more »

13 June 2022 – Sometimes, patients genetics can be bewildering and/or unjust. Common belief with patients and the general public would be that genetic variants would be responsible for causing all kinds of adverse drug reactions (ADR’s) and be at the …

Rare APOE genetic variants reduce Alzheimer’s risk Read more »

09 June 2022 – The individium in general and the patient in the context discussed here, are the phenotype experts on their forms of proper disease they are suffering from. It is not their treating physician, it is not a …

Just a reminder: Thasso and the apomediary patient Read more »

May 08, 2022 – Umbralisib (Ukoniq) is a medication for the treatment of marginal zone lymphoma (MZL) and follicular lymphoma (FL). Umbralisib (Ukoniq) inhibits multiple kinases. In biochemical and cell-based assays, Umbralisib inhibited PI3Kδ and casein kinase CK1ε. PI3Kδ is expressed in …

Umbralisib (Ukoniq): Drug recall because increased risk of patient death Read more »

April 30, 2022 – In a very recent report published in PLoS Genetics  by Dr. Verma of the Corporal Michael Crescenz VA Medical Center in Philadelphia, Pennsylvania, US, and colleagues, new data from the Veterans Affairs Million Veteran Program (MVP) has …

Genetic links revealed between severe COVID-19 and other diseases Read more »

April 10, 2022 – Sotrovimab, sold under the brand name Xevudy, is a monoclonal antibody that was available under emergency use authorization (EUA) from the FDA and similar urgency authorisations from several drug regulatory agencies worldwide for the treatment of patients …

SARS-CoV-2 Delta Variant: Resistance Mutations after Sotrovimab Use Read more »

March 10, 2022 – In a new report distributed in “Circulation: Genomic and Precision”, scientists showed that as while numerous African Americans, particularly those with a high African Family extent, have a good lipid profile, they are at a higher …

Genetic variations and social health determinants may lead to higher risk for diabetes in individuals with high African heritage Read more »

February 20, 2022 – Genomics data are currently being produced at unprecedented rates, resulting in increased knowledge discovery and submission to public data repositories. Hopefully, these data assemblies will one day serve the advanced implementation of theragenomics and personalized medicine …

AGMP: The African Genomic Medicine Portal Read more »

February 02, 2022 – The search to better understand the tremendous range of responses to infection with the SARS-CoV-2 virus, from symptom free to critically or even fatally ill has uncovered in some of the sickest patients a handful of rare …

Genetic variants in extremely ill COVID patients explain how fatally sick people may get Read more »