August 16, 2016 – Riociguat (Adempas) is a stimulator of soluble guanylate cyclase (sGC). In Canada, it is approved for and indicated in the treatment of pulmonary hypertension (PH) in three forms: inoperable chronic thromboembolic pulmonary hypertension, persistent or recurrent chronic thromboembolic pulmonary hypertension after surgical …

Patient Safety: Contraindication for Riociguat (Adempas) Read more »

August 08, 2016 –The following publication has just been released by the EMA. Because Thasso Post is not only about theragenomic and personalized medicine, but also about the safety of medicines for each individual patient, thasso feels that this is …

Patient safety: EMA recommends suspension of medicines over flawed studies Read more »

July 26, 2016  – Renal cell carcinoma is the most common form of kidney cancer in adults. Advanced renal cell carcinoma includes both metastatic disease and locally advanced renal cell carcinoma that cannot be removed by surgery. Despite the recent …

Cabometyx and Kisplyx: Two new medicines for advanced kidney cancer Read more »

July 12, 2016 – The American Food & Drug Administration (FDA) has notified Juno Therapeutics Inc. that a clinical hold has been placed on the Phase II clinical trial of JCAR015 in adult patients with relapsed or refractory B cell acute …

Immunemodulation: Cancer drug trial halted after three test subjects die Read more »

July 9, 2016 – This is a huge step into the future of theragenomic and personalized medicine and individualized drug safety. In support of the President’s Precision Medicine Initiative (PMI), the American Food & Drug Administration (FDA) just issued two …

Precision Medicine Initiative: draft guidances issued Read more »

June 16, 2016 – The sodium-glucose cotransporter 2 (SGLT2) is a protein that is encoded by the SLC5A2 gene. SGLT2 is one member of a larger family of sodium-glucose cotransporters which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney. SGLT2 inhibitors are called gliflozins and …

Sodium-glucose cotransporter-2 (SGLT2) inhibitors in Type-2 Diabetes: Risk of acute kidney injury Read more »

June 08, 2016 – In the United States, Loperamide (Imodium) is approved to help control symptoms of diarrhea, including Travelers’ Diarrhea. The maximum approved daily dose for adults is 8 mg per day for the Over-the-Counter (OTC)-form and 16 mg per …

From diarrhea to long QT: Serious heart problems with high doses of Loperamide (Imodium) from abuse and misuse Read more »

May 30, 2016 – Ghana’s Food and Drugs Authority (FDA) has resolved to ban the sale of cosmetic products which contain the skin bleaching ingredient hydroquinone, effective August this year. The decision, which forms part of a directive from the state’s Standard …

Ghana to Ban Sale of Skin Bleaching Products as of August 2016 Read more »

May 17, 2016 – It has taken quite some time, but finally the American Food & Drug Administration (FDA) advises to restrict the use of fluoroquinolone antibacteril drugs for the use in certain uncomplicated infections and warns about disabling side effects that …

Fluoroquinolone antibacterial drugs: FDA advises restricting use for certain uncomplicated infections Read more »

May 5, 2016 – Today, the American Food and Drug Administration (FDA) finalized a rule extending its authority to all tobacco products, including e-cigarettes, cigars, hookah tobacco and pipe tobacco, among others, which includes the barring of sales of these products to teens …

FDA: Sweeping new federal ruling bars e-cigarette sales to teens younger than 18 Read more »