September 09.  2016 – The pre-clinical animal model and Phase 1b placebo-controlled study in prodromal and mild Alzheimer Disease (AD) patients (n=165), both demonstrate that aducanumab reduced amyloid-beta in the brain and the reduction was dose-dependent. Amyloid-beta plaque is associated …

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease Read more »

September 06, 2016 – Genetic mutations associated with acquired resistance to PD-1 blockade in melanoma have been suspected to be involved in the clinical observation that while approximately 75% of objective responses to anti–programmed death 1 (PD-1) therapy in patients with …

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Read more »

November 27, 2014 – A drug which makes a wide range of cancers more vulnerable to the body’s immune system is “exciting” and may mark a new era, say doctors. The drug MPDL3280A strips cancer cells of the “camouflage” they use to …

Exciting new drug breakthrough in bladder cancer Read more »

June 20, 2014 – The genetic bad actor BRCA2 has been implicated in yet another cancer. The gene is known to increase risk for breast and ovarian cancers. Now, as a new genomic study shows, a rare variant of the …

BRCA2 Variant Linked to Lung Cancer Risk Read more »

May 31, 2014 – This article is from the latest issue of the ANL Magazine. – Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer …

Melanoma of the Eye Caused by Two Gene Mutations Read more »

March 08, 1014 – The following article just appeared in PsyBlog and provides highly interesting reading in relation to newly discovered molecular mechanisms in the etiology of (possibly individualized) disease predispositions. Very exciting. The most common form of intellectual disability is caused by a mechanism which shuts …

Genetic Trigger Discovered For Most Common Form of Mental Disability and Autism Read more »

May 09, 2013 – We have just stumbled upon a recent press release to the public by the American Food and Drug Administration (FDA) on a looming drug safety problem of incretin mimetic drugs related to the pancreas. Find here …

Incretin Mimetic Drugs for Type 2 Diabetes: Early Communication – Reports of Possible Increased Risk of Pancreatitis and Pre-cancerous Findings of the Pancreas Read more »

April 05, 2010 – A very recent article by msnbc.com indicates that thalidomide, a drug that caused birth defects when it was launched as a morning sickness pill half a century ago, may be useful for treating a hereditary condition …

Thalidomide may fight blood vessel disorder: Nosebleeds eased with once-maligned drug Read more »

February 21, 2010 – In the field of pharmaco- and toxicogenetics of serious adverse drug reactions (sADRs) in humans, we learn today from a press release by the US Food and Drug Administration (FDA) of the completion and release by …

Regulatory Science Update: FDA and International Serious Adverse Events Consortium (SAEC) Complete Third Data Release Read more »