Blog Archives

Wo sich Porträtfotos mit Genetik und KI treffen

13. Juni 2019 – Das ist einfach faszinierende Wissenschaft und Medizin. Die Forscher testen neuronale Netzewerke, die automatisch Porträtfotos mit genetischen und phänotypischen Patientendaten kombinieren, um mit Hilfe der künstlichen Intelligenz (KI) eine endgültige Diagnose erblich bedingter seltener Krankheiten zu erhalten. In einer im Journal of Genetics in Medicine veröffentlichten Studie mit 679 Patienten mit 105 seltenen Krankheiten hat ein interdisziplinäres Wissenschaftlerteam gezeigt,

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Iberogast: Pharmafirmen wie Autobauer. Täuschung der Kunden und Patienten für Profit

20. Oktober 2018 – Das in der traditionellen chinesischen Medizin und in der Naturheilkunde mit verschiedenen therapeutischen Wirkungen assoziierte Schöllkraut hat eine potenziell lebertoxische Wirkung. Aufgrund dieser Lebertoxizität von Schöllkraut wurde bereits 2008 allen Phytopharmaka mit einer Tagesdosis von mehr als 2,5 mg Chelidonium-Gesamtalkaloiden die Zulassung entzogen.

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Immunvermittelte nekrostisierende Myopathie: Eine seltene, jedoch bedrohliche Nebenwirkung unter Statin-Therapie

13. November 2015 – In den letzten Jahren wurden Statine (HMG-CoA-Reduktasehemmer) als ein möglicher Auslöser der seltenen immunvermittelten nekrotisierenden Myopathie (englisch als immune-mediated necrotising myopathy (IMNM) bezeichnet) identifiziert.

Swissmedic (Das Schweizerische Heilmittelinstitut) hat dazu am 21. Oktober 2015 eine sogenannte HPC (Health Profesional Communication) veröffentlicht.

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Rodapitant (Varubi) als eine neue Behandlung für Übelkeit und Erbrechen nach Chemotherapie zugelassen

2. September 2015 – phase die US Food and Drug Administration zugelassenen Rodapitant (Varubi) um zu vermeiden verzögert, Chemotherapie-induzierter Übelkeit und Erbrechen (Erbrechen). Rodapitant (Varubi) wird bei Erwachsenen in Kombination mit anderen Drogen (brechreizhemmende Agenten), die Übelkeit zu verhindern genehmigt und Erbrechen im Zusammenhang mit aus- und wiederholen-Kurse von Erbrochenem-induzierende (emetogenen und hoch emetogenen) Krebs-Chemotherapie.

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Droge-Sicherheit-Kommunikation: DPP-4-Inhibitoren für Typ 2-Diabetes können schwere Gelenkschmerzen verursachen.

29. August 2015 – dies immerhin also gute Nachrichten für Typ-2-Diabetikern über DPP-4-Hemmer Medikamente möglicherweise nicht. Der amerikanischen Food and Drug Administration (FDA) warnt, dass die pharmakologisch wirksamen Bestandteile (PAI) Sitagliptin, Saxagliptin Linagliptin und Alogliptin mit Typ 2 Diabetes Medikamente Gelenkschmerzen verursachen können, die schwere und behindernden sein können.  

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A potentially life-saving drug safety communication: FDA strengthens warning of increased chance of heart attack or stroke on non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs)

July 15, 2015 – This post comes directly from FDA, and it may not only be live-saving information for patients in the US, but all over the world, including the Africa’s, Europe, and Asia. 

The ISSUE: FDA is strengthening an existing drug label warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke.

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Cangrelor (Kengreal) a newly approved antiplatelet drug used during PCI heart procedure

June 26, 2015 –  The following is good news for patients who will need percutaneous coronary intervention (PCI), however, bleeding problems are not completely resolved. But see for yourself.

The U.S. Food and Drug Administration just approved Cangrelor (Kengreal), an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries,

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Eliglustat [Cerdelga] approved for the treatment of a form of Gaucher Disease

August 22. 2014 – On August 19, 2014, the U.S. Food and Drug Administration approved Cerdelga (eliglustat) for the long-term treatment of adult patients with the Type 1 form of Gaucher disease, a rare genetic disorder.

Gaucher disease occurs in people who do not produce enough of an enzyme called glucocerebrosidase.

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FDA approves first non-invasive DNA screening test for colorectal cancer

August 11. 2014 – The U.S. Food and Drug Administration today approved Cologuard, the first stool-based colorectal screening test that detects the presence of red blood cells and DNA mutations that may indicate the presence of certain kinds of abnormal growths that may be cancers such as colon cancer or precursors to cancer.

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Genetic Trigger Discovered For Most Common Form of Mental Disability and Autism

March 08, 1014 – The following article just appeared in PsyBlog and provides highly interesting reading in relation to newly discovered molecular mechanisms in the etiology of (possibly individualized) disease predispositions. Very exciting.

The most common form of intellectual disability is caused by a mechanism which shuts of an associated gene,

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  • Development and analytical validation of a next-generation sequencing based microsatellite instabili October 18, 2019
    The referenced article describes an assay that has a clinically relevant five-day turnaround time and can be conducted on as little as 20 ng genomic DNA with a batch size of up to forty samples in a single run.
  • Lifestyle is a threat to gut bacteria: Ötzi proves it October 18, 2019
    The intestinal microbiome is a delicate ecosystem made up of billions and billions of microorganisms, bacteria in particular, that support our immune system, protect us from viruses and pathogens, and help us absorb nutrients and produce energy. The industrialization process in Western countries had a huge impact on its content. This was confirmed by a […]
  • Singapore completes whole genome sequencing analysis of multi-ethnic Asian populations October 18, 2019
    A new genetic databank has been established containing the completed whole-genome sequencing (WGS) data of close to 5,000 Singaporeans. Worldwide, WGS is increasingly used in research and healthcare to identify genetic variations using cutting-edge technologies that allow large numbers of individuals to be sequenced rapidly—This new study is the world's largest WGS analysis of Asian […]
  • Researchers quantify limitations of health reports from direct-to-consumer genetic tests October 17, 2019
    Health reports from direct-to-consumer (DTC) genetic tests that use a limited variant screening approach often yield clinical false-negative results, which pose the risk of informing health care decisions based on incomplete information, according to findings presented at the American Society of Human Genetics (ASHG) 2019 Annual Meeting in Houston, Texas.
  • Researchers develop mouse model of human gene involved in Alzheimer's disease October 17, 2019
    In research that helps scientists better understand and explore treatments for diseases like Alzheimer's, scientists have developed a line of mice in which the mouse version of the Alzheimer's-associated MAPT gene has been fully replaced by the human version of the gene. In this new animal model, known as a full gene-replacement model, the MAPT […]
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