the glocalized network in theragenomic and personalized medicine and the genetics of individual patients safety of drugs
25 June 2022 – Xalkori (Crizotinib)-related ocular toxicity and severe visual loss are difficult to detect in children. This comes out of a Dear Healthcare Professional Communication (DHPC) letter from the European Medicine Agency (EMA) following it’s June 2022 Pharmacovigilance Risk Assessment …
Xalkori: Ocular Toxicity and Severe Visual Loss in Children Read more »
13 June 2022 – Sometimes, patients genetics can be bewildering and/or unjust. Common belief with patients and the general public would be that genetic variants would be responsible for causing all kinds of adverse drug reactions (ADR’s) and be at the …
Rare APOE genetic variants reduce Alzheimer’s risk Read more »
09 June 2022 – The individium in general and the patient in the context discussed here, are the phenotype experts on their forms of proper disease they are suffering from. It is not their treating physician, it is not a …
Just a reminder: Thasso and the apomediary patient Read more »
May 08, 2022 – Umbralisib (Ukoniq) is a medication for the treatment of marginal zone lymphoma (MZL) and follicular lymphoma (FL). Umbralisib (Ukoniq) inhibits multiple kinases. In biochemical and cell-based assays, Umbralisib inhibited PI3Kδ and casein kinase CK1ε. PI3Kδ is expressed in …
Umbralisib (Ukoniq): Drug recall because increased risk of patient death Read more »
July 14, 2021 – Why does a SARS-CoV-2 infection make some people so sick with Covid-19 disease? And why do some infected people barely fall ill if at all? The answer may be that you have to talk to their …
Genetic susceptibility and severity loci for Covid-19 disease Read more »
June 30, 2021 – This post is based on an overview given by the Centers of Disease Control (CDC) of the United States on the current knowledge on the occurrence of severe adverse effects (SAE) after anti-Covid-19 vaccination as reported …
Serious adverse events after Covid-19 vaccination occur but are very rare Read more »
March 28, 2021 – Recent reports from the United Kingdom (UK) and from throughout the European Union (EU) have suggested that the SARS-CoV-2 (Covid-19) vaccine made by AstraZeneca was at the origin of the development of a very rare type …
Covid-19 Vaccines: Is there genetic predisposition for thrombosis? Read more »
February 08, 2021 – In the period of the Covid-19 pandemic and the emerging spectrum of severe adverse (drug) reactions (SADRs) of the anti-Covid-19 vaccines in some patients receiving these vaccines, one easily forgets about the same phenomenon of SADRS …
Fingolimod (Gilenya): Warnings on severe liver failures Read more »
January 26, 2021 – To date, a rare serious adverse (drug) reaction (SADR) has been noted to be associated with the first two Covid-19 vaccines, i.e., the one from Pfizer-BioNTech and the one from Moderna. We are talking about anaphylaxis, which …
Rare cases of anaphylaxis with COVID-19 vaccines Read more »
December 28, 2020 – Some 95% of people have gene variants that may negatively affect their response to at least one drug, leading to unexpected or adverse drug reactions (ADRs) or, if unlucky, to a serious, if not fatal, adverse …
Genetics behind some serious adverse drug reactions (SADRs) Read more »