theragenomics: drug labels with annotated information

thasso provides the present information via PharmGKB which constantly annotates drug labels and or product monographs containing pharmacogenetic (i.e., theragenomic) information approved by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), Swiss Agency of Therapeutic Products (Swissmedic), the Pharmaceuticals and Medical Devices Agency, Japan (PMDA), and Health Canada (Santé Canada) (HCSC). PharmGKB annotations provide a brief summary of the pharmacogenetic information in the label, an excerpt from the label and a downloadable PDF file of the label in question with the respective  pharmacogenetic information highlighted.  A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the “PGx Level” tag.

Direct links to any of the informations in the below table can be found at PharmGKB Drug Label Annotations.

 

DrugBiomarkerFDAEMASwissmedicPMDAHCSC
abacavirOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Informative PGxTesting required
abemaciclibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
acenocoumarolActionable PGx
acetaminophenActionable PGx (prescribing info)Actionable PGx
acetaminophen / codeineTesting required (alternative drug / prescribing info), Actionable PGx
acetaminophen / tramadolActionable PGx (prescribing info)
afatinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required (cancer genome / prescribing info)
afutuzumabOff (Formerly On)Informative PGx (cancer genome)Informative PGx
alectinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
alglucosidase alfaOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
alirocumabOff (Formerly On)Informative PGx
aliskirenInformative PGxInformative PGx
allopurinolActionable PGx (prescribing info)Actionable PGx
alpelisibOnTesting required (cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
amifampridineOnActionable PGx (dosing info / prescribing info)
amifampridine phosphateOnActionable PGx (dosing info / prescribing info)Actionable PGx, Actionable PGxActionable PGxActionable PGx (dosing info / prescribing info)
amitriptylineOnActionable PGx
amlodipine / atorvastatin / perindopril arginineActionable PGx
amoxapineOnActionable PGx
amphetamineOnInformative PGx
anastrozoleOnTesting required (cancer genome / prescribing info)Testing required
antithrombotic agentsActionable PGx
arformoterolOnInformative PGx
aripiprazoleOnActionable PGx (dosing info / prescribing info)Actionable PGx (dosing info / prescribing info)Actionable PGxActionable PGx
aripiprazole lauroxilOnActionable PGx (dosing info / alternative drug / prescribing info)
arsenic trioxideOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
articaine / epinephrineOnActionable PGx (prescribing info)
aspirinActionable PGx
atazanavirTesting recommendedActionable PGxInformative PGx
atezolizumabOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (cancer genome / prescribing info)
atomoxetineOnActionable PGx (dosing info / prescribing info)Actionable PGxActionable PGxActionable PGx
atorvastatinOff (Formerly On)Informative PGxInformative PGxInformative PGx
avapritinibOnTesting required (alternative drug / prescribing info)
avatrombopagOnActionable PGx, Informative PGx
avelumabOnInformative PGx (cancer genome)
axitinibInformative PGx
azathioprineOnTesting recommended (prescribing info)Actionable PGx (dosing info / prescribing info)Actionable PGxActionable PGx
belimumabOff (Formerly On)Informative PGxInformative PGxInformative PGx
belinostatOnActionable PGx (dosing info / prescribing info)
binimetinibOnTesting required (alternative drug / cancer genome / prescribing info), Informative PGxTesting required (alternative drug / cancer genome / prescribing info), Informative PGx
bisoprolol fumarate / perindopril arginineActionable PGx
blinatumomabOnInformative PGx (cancer genome)
boceprevirOnInformative PGxActionable PGxInformative PGx
bosutinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required
brentuximab vedotinOnInformative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Informative PGx
brexpiprazoleOnActionable PGx (dosing info / prescribing info)Actionable PGx (dosing info / prescribing info)Actionable PGx (dosing info / prescribing info)
brigatinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
brivaracetamOnActionable PGx (prescribing info)Actionable PGxInformative PGxActionable PGx
bupropionOnInformative PGx
busulfanOnActionable PGx (cancer genome / prescribing info)
cabazitaxelInformative PGx
cabozantinibOnInformative PGx
capecitabineOnActionable PGx (prescribing info)Testing recommended (alternative drug / prescribing info)Actionable PGx (dosing info / alternative drug / prescribing info)Actionable PGxActionable PGx
capmatinibOnTesting required (alternative drug / cancer genome / prescribing info)
carbamazepineOnTesting required (alternative drug / prescribing info), Actionable PGxTesting required (alternative drug / prescribing info), Testing recommended (alternative drug / prescribing info)Actionable PGxTesting recommended
carbasalate calciumActionable PGx
carglumic acidOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Testing required
cariprazineOnInformative PGx
carisoprodolOnActionable PGx (prescribing info)
carvedilolOnActionable PGxInformative PGxActionable PGx
ceftriaxoneOnActionable PGx (prescribing info)
celecoxibOnActionable PGx (dosing info / prescribing info)Actionable PGxActionable PGxActionable PGx
ceritinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required
cerliponase alfaOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
cetuximabOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
cevimelineOnActionable PGx (prescribing info)
chloroprocaineOnActionable PGx
chloroquineOnActionable PGx (prescribing info)Actionable PGx (alternative drug / prescribing info)
chlorpropamideOnActionable PGx (prescribing info)Actionable PGx
cholic acidOff (Formerly On)Testing required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
ciprofloxacinActionable PGx
cisplatinOnInformative PGx
citalopramOnActionable PGx (dosing info / prescribing info), Informative PGxActionable PGx (dosing info / prescribing info)Actionable PGx
clobazamOnActionable PGx (dosing info / prescribing info)
clomipramineOnActionable PGxActionable PGx
clopidogrelOnActionable PGx (prescribing info)Actionable PGxActionable PGx (dosing info / prescribing info)Actionable PGxActionable PGx
clozapineOnActionable PGx (prescribing info)
cobimetinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
codeineOnActionable PGx (alternative drug / prescribing info)Actionable PGx (alternative drug / prescribing info)Actionable PGxActionable PGx
crizanlizumab-tmcaOnInformative PGx
crizotinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
dabrafenibOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGx, Informative PGxTesting required (alternative drug / cancer genome / prescribing info)Testing required
daclatasvirOnInformative PGxInformative PGx
dacomitinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
dapoxetineActionable PGx (dosing info / prescribing info)
dapsoneOnActionable PGxActionable PGxActionable PGx
darifenacinOnActionable PGxActionable PGxActionable PGxActionable PGx
darunavirInformative PGx
dasabuvirActionable PGx
dasabuvir / ombitasvir / paritaprevir / ritonavirOnInformative PGx
dasatinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
denileukin diftitoxOnTesting required (alternative drug / cancer genome / prescribing info)
desfluraneOnActionable PGx (alternative drug / prescribing info)Actionable PGx
desipramineOnActionable PGx
desloratadineInformative PGx
desvenlafaxineOnInformative PGx
deutetrabenazineOnActionable PGx (dosing info / prescribing info)
dexlansoprazoleOnActionable PGxActionable PGxActionable PGx
dextromethorphanActionable PGx
dextromethorphan / quinidineOnTesting recommendedActionable PGx (prescribing info)
diazepamOnActionable PGx
dinutuximabOnInformative PGx (cancer genome)
divalproex sodiumOff (Formerly On)Testing required (alternative drug / prescribing info)Testing required
docetaxelOnInformative PGx (cancer genome)
dolutegravirOnActionable PGxActionable PGxInformative PGx
dolutegravir / abacavir / lamivudineTesting required (prescribing info)
donepezilOnActionable PGx
dotatate lutenium lu-177OnTesting required (alternative drug / cancer genome / prescribing info)
doxepinOnActionable PGx
dronabinolOnActionable PGx (prescribing info)
dronedaroneInformative PGx
drospirenone / ethinyl estradiolOnInformative PGxActionable PGx
duloxetineOnActionable PGxActionable PGxActionable PGx
durvalumabOnInformative PGx (cancer genome)
duvelisibOnInformative PGx (cancer genome)
eculizumabOnTesting required (alternative drug / prescribing info)
efavirenzOnActionable PGxActionable PGxActionable PGxActionable PGx
efavirenz / emtricitabine / tenofovir disoproxilActionable PGxActionable PGx
elagolixOnActionable PGx
elbasvir / grazoprevirOnInformative PGx
eletriptanInformative PGx
elexacaftor / tezacaftor / ivacaftorOnTesting required (alternative drug / prescribing info)
eliglustatOnTesting required (dosing info / prescribing info)Testing required (dosing info / alternative drug / prescribing info)Testing required
elosulfase alfaOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
eltrombopagOnActionable PGxActionable PGx (prescribing info)Actionable PGxActionable PGx
emapalumabOnInformative PGx
enasidenibOnTesting required (alternative drug / cancer genome / prescribing info)
encorafenibOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGx (cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
enfluraneOff (Formerly On)Actionable PGx (alternative drug / prescribing info)
enfortumab vedotinOnInformative PGx
entrectinibOnTesting required (alternative drug / cancer genome / prescribing info)
erdafitinibOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGx (prescribing info)
eribulinOnInformative PGx (cancer genome)
erlotinibOnTesting required (alternative drug / cancer genome / prescribing info)Actionable PGx, Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
erythromycin ethylsuccinate / sulfisoxazole acetylOnActionable PGxActionable PGx
escitalopramOnActionable PGx, Informative PGxInformative PGx, Actionable PGx (dosing info / prescribing info)Actionable PGx
esomeprazoleOnActionable PGxInformative PGx (prescribing info)Informative PGx
estradiol / progesteroneOnActionable PGx (prescribing info)
eteplirsenOnTesting required (alternative drug / prescribing info)
ethinyl estradiol / norelgestrominActionable PGx (alternative drug / prescribing info)Actionable PGx
everolimusOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
evolocumabOff (Formerly On)Informative PGx
exemestaneOnTesting required (alternative drug / cancer genome / prescribing info)Testing required
ezetimibe / rosuvastatinActionable PGx (prescribing info)
ezetimibe / simvastatinTesting recommended (dosing info / prescribing info)
fampridineInformative PGx
fam-trastuzumab deruxtecan-nxkiOnTesting required (alternative drug / cancer genome / prescribing info)
fenofibrateActionable PGx
fesoterodineOnActionable PGxActionable PGxActionable PGxActionable PGxActionable PGx
flibanserinOnActionable PGx
flucloxacillinActionable PGx
flucytosineTesting recommended
fluorouracilOnActionable PGx (alternative drug / prescribing info)Testing required, Actionable PGxActionable PGxActionable PGx
fluorouracil / salicylic acidTesting recommended
fluoxetineOnInformative PGxInformative PGx
fluoxetine / olanzapineOff (Never On)Actionable PGx
flurbiprofenOnActionable PGx (dosing info / prescribing info)
flutamideOnActionable PGx
fluvoxamineOnActionable PGxActionable PGx
formoterolOnInformative PGx
fosamprenavirInformative PGx
fosphenytoinOnActionable PGx (prescribing info)
fulvestrantOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required
galantamineOnInformative PGx (prescribing info)Actionable PGxInformative PGx
gefitinibOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGx (prescribing info)Testing required (alternative drug / cancer genome / prescribing info), Actionable PGx (prescribing info)Actionable PGxTesting requiredTesting required
gemtuzumab ozogamicinOnTesting required (alternative drug / cancer genome / prescribing info)
gilteritinibOnTesting required (alternative drug / cancer genome / prescribing info)
givosiranOnInformative PGx
glibenclamideOff (Formerly On)Actionable PGx (prescribing info)Actionable PGx (alternative drug / prescribing info)Actionable PGxActionable PGx
gliclazideActionable PGx
glimepirideOnActionable PGx (prescribing info)Actionable PGx (prescribing info)Actionable PGxActionable PGx
glipizideOnActionable PGx (prescribing info)
golodirsenOnTesting required (alternative drug / prescribing info)
goserelinOnInformative PGx
haloperidolActionable PGx
homoharringtonineOff (Formerly On)Informative PGx (cancer genome)
hydralazine / isosorbide dinitrateOnInformative PGx
hydroxychloroquineOnActionable PGx (prescribing info)Actionable PGx
ibritumomabOff (Formerly On)Informative PGx (cancer genome)Informative PGx
ibrutinibOnTesting required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome)Testing required (cancer genome / prescribing info)Informative PGxTesting required
iloperidoneOnActionable PGx (dosing info / prescribing info)
imatinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
imipramineOnActionable PGx
indacaterolOnInformative PGxInformative PGxInformative PGxActionable PGx
indinavirInformative PGx
inebilizumab-cdonOnTesting required (alternative drug / prescribing info)
inotersenOnInformative PGx
inotuzumab ozogamicinOnInformative PGx (cancer genome)
ipilimumabOnInformative PGx, Testing required (alternative drug / cancer genome / prescribing info)
irinotecanOnActionable PGx (dosing info / prescribing info)Actionable PGx (prescribing info)Actionable PGx (dosing info / prescribing info)Testing recommendedActionable PGx
isatuximab-irfcOnInformative PGx (cancer genome)
isofluraneOnActionable PGx (alternative drug / prescribing info)Actionable PGx
isoniazidInformative PGx
isoniazid / pyrazinamide / rifampinOnInformative PGx
isosorbide dinitrateOnInformative PGx
isosorbide mononitrateOnInformative PGx
ivabradineInformative PGx
ivacaftorOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Testing required
ivacaftor / lumacaftorOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
ivacaftor / tezacaftorOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
ivosidenibOnTesting required (alternative drug / cancer genome / prescribing info)
ixabepiloneOnInformative PGx (cancer genome)
lacosamideOnInformative PGxInformative PGx
lamivudine / abacavirTesting required (prescribing info)
lansoprazoleOnInformative PGxActionable PGx
lapatinibOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGxActionable PGx, Testing required (alternative drug / cancer genome / prescribing info)Actionable PGxTesting requiredTesting required
larotrectinib sulfateOnTesting required (alternative drug / cancer genome / prescribing info)
ledipasvir / sofosbuvirOnInformative PGx
lenalidomideOnTesting requiredInformative PGxInformative PGxInformative PGx
lenvatinibOnTesting required (alternative drug / cancer genome / prescribing info)
lesinuradOnActionable PGx (prescribing info)Actionable PGx (prescribing info)Informative PGx
letermovirInformative PGx
letrozoleOnTesting required (alternative drug / cancer genome / prescribing info)Actionable PGxTesting required
lidocaine and tetracaineOnActionable PGx (prescribing info)
lidocaine / prilocaineOnActionable PGxActionable PGx
lofexidineOnActionable PGx (prescribing info)
lomitapideOff (Formerly On)Informative PGxTesting requiredInformative PGx
lorlatinibOnTesting required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome)Testing required (alternative drug / cancer genome / prescribing info)
losartanActionable PGx
luspatercept-aamtOnInformative PGx
lusutrombopagOnActionable PGx
mafenideOnActionable PGx
maravirocOff (Formerly On)Informative PGxActionable PGx
meclizineOnActionable PGx (prescribing info)
mefloquineInformative PGx
meloxicamOnActionable PGx (prescribing info)
mepivacaineOnActionable PGx (prescribing info)
mercaptopurineOnTesting recommended (dosing info / prescribing info)Actionable PGx (prescribing info)Actionable PGx (prescribing info)Actionable PGx
metabutethamineActionable PGx (prescribing info)
methylene blueOnActionable PGx (alternative drug / prescribing info)Actionable PGx (alternative drug / prescribing info)Actionable PGx
metoclopramideOnActionable PGx, Actionable PGx (dosing info / prescribing info)
metoprololOnInformative PGxActionable PGxActionable PGx
midostaurinOnInformative PGx, Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
migalastatOnTesting required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)
mipomersenOff (Formerly On)Informative PGx
mirabegronOnActionable PGxInformative PGx (prescribing info)Informative PGx
mivacurium chlorideOnActionable PGx (prescribing info)Actionable PGx
moclobemideActionable PGx
modafinilOnActionable PGx
moviprepOff (Formerly On)Actionable PGx (prescribing info)Actionable PGxActionable PGx
moxifloxacinActionable PGx (prescribing info)
mycophenolic acidOnActionable PGx (alternative drug / prescribing info)Actionable PGxActionable PGx
nalidixic acidOnActionable PGx (prescribing info)Actionable PGx
nebivololOnInformative PGx (prescribing info)Informative PGx
nefazodoneOnInformative PGx (prescribing info)
nelfinavirOff (Formerly On)Informative PGxInformative PGx
neratinibOnInformative PGx, Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
nicorandilActionable PGx (prescribing info)
nilotinibOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGxTesting required (alternative drug / cancer genome / prescribing info)Actionable PGx, Testing required
niraparibOnTesting required (alternative drug / cancer genome / prescribing info)
nitrofurantoinOnActionable PGxActionable PGx (alternative drug / prescribing info)Actionable PGx
nitroglycerinActionable PGx
nivolumabOnInformative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info)
norfloxacinOff (Never On)Actionable PGxActionable PGxActionable PGx
nortriptylineOnActionable PGxActionable PGx
nusinersenOnInformative PGx
ofatumumabOff (Formerly On)Informative PGx (cancer genome)Informative PGx
ofloxacinActionable PGx (prescribing info)
olanzapineInformative PGx
olaparibOnInformative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
olaratumabOnInformative PGx (cancer genome)
oliceridineOff (Never On)Actionable PGx (prescribing info)
ombitasvir / paritaprevir / ritonavirOnInformative PGxActionable PGx
omeprazoleOnActionable PGxActionable PGxInformative PGxInformative PGx
ondansetronOnInformative PGxInformative PGx
Opium derivatives and expectorantsActionable PGx
osimertinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
ospemifeneOnInformative PGx
oxcarbazepineOnTesting recommended (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Testing recommended (alternative drug / prescribing info)
oxycodoneActionable PGx
oxymetazoline and tetracaineOnActionable PGx (prescribing info)
palbociclibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
paliperidoneOnInformative PGxInformative PGx
palonosetronOnInformative PGxInformative PGxInformative PGx
panitumumabOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
pantoprazoleOnActionable PGx (prescribing info)Informative PGx
Paracetamol, combinations excl. Psycholeptics (Vicks MediNait Sirup)Actionable PGx (prescribing info)
Parathyroid Hormones And AnaloguesOnInformative PGx
paroxetineOnInformative PGx
pazopanibOnActionable PGxActionable PGxActionable PGx
peginterferon alfa-2bOnActionable PGx
pegloticaseOnTesting required (alternative drug / prescribing info)Testing required
pembrolizumabOnTesting required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome)Testing required (alternative drug / cancer genome / prescribing info)
perindoprilActionable PGx
perphenazineOnActionable PGxActionable PGx
pertuzumabOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGx (cancer genome)Testing required (alternative drug / cancer genome / prescribing info)Testing required
phenytoinOnActionable PGx (prescribing info)Actionable PGx (dosing info / prescribing info)Testing recommended
pimozideOnTesting required (dosing info / prescribing info)
pioglitazoneActionable PGx (prescribing info)
piroxicamOnActionable PGx (prescribing info)Actionable PGx
pitavastatinActionable PGx
pitolisantOnActionable PGx (dosing info / prescribing info)
ponatinibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required
posaconazoleInformative PGx
prasugrelOnInformative PGxInformative PGxInformative PGx
pravastatinOff (Formerly On)Informative PGx, Informative PGx
prilocaineActionable PGx
primaquineOnTesting required (alternative drug / prescribing info), Actionable PGxActionable PGx
probenecidOnActionable PGx
procainamideOnInformative PGx (prescribing info)
propafenoneOnActionable PGx (prescribing info)Actionable PGxActionable PGx
propranololOnInformative PGxInformative PGx
protriptylineOnActionable PGx
quinidineOnInformative PGx
quinineOnActionable PGx (prescribing info)Actionable PGx (alternative drug / prescribing info)Actionable PGx
rabeprazoleOnActionable PGxActionable PGxActionable PGxActionable PGx
raloxifeneOnInformative PGx
raltegravirOnInformative PGxInformative PGx (prescribing info)
ramucirumabOnInformative PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome)
ranolazineActionable PGxActionable PGx (prescribing info)
rasburicaseOnInformative PGx, Testing required (alternative drug / prescribing info)Actionable PGx (alternative drug / prescribing info)Actionable PGx (alternative drug / prescribing info)Actionable PGxTesting recommended
regorafenibOnInformative PGx (cancer genome)Actionable PGx (cancer genome)
ribociclibOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
rimegepantOnInformative PGx
risperidoneOnInformative PGx (prescribing info)Informative PGxInformative PGx
ritonavirInformative PGx
rituximabOnInformative PGx (cancer genome)Testing required
rivaroxabanOnInformative PGx
ropivacaineOnActionable PGx
rosuvastatinOnActionable PGxActionable PGx (prescribing info)Actionable PGx
rucaparibOnInformative PGx, Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info), Informative PGx
ruxolitinibInformative PGx
sacituzumab govitecan-hziyOnActionable PGx (prescribing info)
selpercatinibOnTesting required (alternative drug / cancer genome / prescribing info)
sertindoleActionable PGx
sevofluraneOnActionable PGx (alternative drug / prescribing info)Actionable PGx
sildenafilInformative PGx
simeprevirOnInformative PGxInformative PGx
simvastatinActionable PGx, Testing recommended (prescribing info)
siponimodOnTesting required (dosing info / alternative drug / prescribing info)
sirolimusInformative PGx
sodium benzoate / sodium phenylacetateOff (Formerly On)Testing required
sodium nitriteOnActionable PGx (prescribing info)Actionable PGx
sodium phenylbutyrateOnTesting requiredInformative PGx (alternative drug / prescribing info)Testing required
sofosbuvirOnInformative PGxActionable PGx (prescribing info)
sofosbuvir / velpatasvirOnInformative PGx
sofosbuvir / velpatasvir / voxilaprevirOnInformative PGx
succimerOnInformative PGx
succinylcholineOnActionable PGx (alternative drug / prescribing info)Actionable PGx
sulfadiazineOnActionable PGxActionable PGxActionable PGxActionable PGx
sulfamethoxazole / trimethoprimOnActionable PGxActionable PGxActionable PGxActionable PGx
sulfasalazineOnActionable PGx (prescribing info)Actionable PGxActionable PGxActionable PGx
sunitinibInformative PGx
tafamidisOnInformative PGx
tafenoquineOnTesting required (alternative drug / prescribing info)
talazoparibOnTesting required (alternative drug / prescribing info), Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)
tamoxifenOnTesting required (alternative drug / cancer genome / prescribing info), Actionable PGx, Informative PGxActionable PGxTesting required
tamsulosinOnActionable PGx (prescribing info)Actionable PGx
telaprevirOnActionable PGxActionable PGx
telithromycinInformative PGx
terbinafineOff (Formerly On)Informative PGx
tetrabenazineOnTesting required (dosing info / prescribing info)Testing required (prescribing info)Actionable PGxActionable PGx
thioguanineOnTesting recommended (dosing info / prescribing info)Actionable PGx (dosing info / prescribing info)Actionable PGx
thioridazineOnActionable PGx (alternative drug / prescribing info)
ticagrelorOnInformative PGxActionable PGx
timololInformative PGx
tiotropiumOff (Formerly On)Informative PGx
tipiracil / trifluridineOnTesting required (cancer genome / prescribing info)
tipranavirInformative PGx
tolazamideOnActionable PGx (prescribing info)
tolbutamideOnActionable PGx (prescribing info)Actionable PGx
tolperisoneActionable PGx
tolterodineOnActionable PGxActionable PGxInformative PGxInformative PGx
toremifeneOnTesting required (cancer genome / prescribing info)Actionable PGx (cancer genome / prescribing info)
tositumomabOff (Formerly On)Informative PGx (cancer genome)
tramadolOnActionable PGx (alternative drug / prescribing info)Actionable PGx
trametinibOnTesting required (alternative drug / cancer genome / prescribing info), Informative PGx, Informative PGx (cancer genome)Testing required (alternative drug / cancer genome / prescribing info)Testing required
trastuzumabOnActionable PGx (cancer genome), Testing required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
trastuzumab emtansineOnTesting required (alternative drug / cancer genome / prescribing info)Testing required (alternative drug / cancer genome / prescribing info)Testing required
tretinoinOnTesting required (alternative drug / cancer genome / prescribing info)Informative PGxTesting required
trimipramineOnActionable PGx
tucatinibOnTesting required (alternative drug / cancer genome / prescribing info)
umeclidiniumOnInformative PGxInformative PGxInformative PGx
umeclidinium / vilanterolInformative PGx
upadacitinibOnInformative PGx
ustekinumabOnInformative PGx
valbenazineOnActionable PGx (prescribing info)
valproic acidOnActionable PGx (alternative drug / prescribing info), Testing required (alternative drug / prescribing info)Actionable PGxActionable PGx
vandetanibTesting recommended (cancer genome), Testing recommended
vardenafilInformative PGx
velaglucerase alfaOff (Formerly On)Testing required (alternative drug / prescribing info)Testing required (alternative drug / prescribing info)Testing required
vemurafenibOnTesting required (alternative drug / cancer genome / prescribing info), Informative PGx (cancer genome)Testing required (alternative drug / cancer genome / prescribing info)Testing requiredTesting required
venetoclaxOnInformative PGx (cancer genome)
venlafaxineOnActionable PGxActionable PGx
vernakalantInformative PGx
vincristineOnTesting required (alternative drug / cancer genome / prescribing info)
Vitamin B-complex with vitamin CActionable PGx
vitamin cActionable PGx (dosing info / prescribing info)
voriconazoleOnActionable PGxInformative PGxActionable PGxActionable PGxActionable PGx
vortioxetineOnActionable PGx (dosing info / prescribing info)Actionable PGx (dosing info / prescribing info)Actionable PGxActionable PGx
voxelotorOnInformative PGx
warfarinOnActionable PGx (prescribing info)Actionable PGx
zidovudine / lamivudine / abacavirTesting required (prescribing info)
zonisamideInformative PGx
zuclopenthixolInformative PGx

 

Legend (how to read);

  • Genetic testing required:  The label states or implies that some sort of gene, protein or chromosomal testing, including genetic testing, functional protein assays, cytogenetic studies, etc., should be conducted before using this drug. 
  • Genetic testing recommended: The label states or implies that some sort of gene, protein or chromosomal testing, including genetic testing, functional protein assays, cytogenetic studies, etc., is recommended before using this drug. 
  • Actionable PGx: The label does not discuss genetic or other testing for gene/protein/chromosomal variants, but does contain information about changes in efficacy, dosage or toxicity due to such variants. 
  • Informative PGx: The label mentions a gene or protein is involved in the metabolism or pharmacodynamics of the drug, but there is no information to suggest that variation in these genes/proteins leads to different response.